Angel Mounds was a permanent settlement of the Mississippian culture from 1000 AD to around 1400 AD. Four NYSE companies (Accuride, Berry Global, Springleaf, and Vectren) are headquartered in Evansville, along with the global operations center for NYSE company Mead Johnson.
Three other companies traded on the NASDAQ (Escalade, Old National Bank, and Shoe Carnival) are also headquartered in Evansville.
The era of Evansville's greatest growth occurred in the second half of the 19th century, following the disruptions of the Civil War.
The city was a major stop for steamboats along the Ohio River, and it was the home port for a number of companies engaged in trade via the river.
Throughout this period Evansville's main ethnic groups consisted of Germans fleeing Europe, Protestant Scotch-Irish from the South, Catholic Irish coming for canal or railroad work, New England businessmen, and newly freed slaves from Western Kentucky.
As the new century began, growth in the city continued to move eastward.
The county was named for Henry Vanderburgh, a deceased chief judge of the Indiana territorial supreme court.
Evansville became a thriving commercial town with a river trade, and the town began to expand outside of its original footprint.
By the time the Wabash and Erie Canal was finished in 1853, Evansville's first railroad, Evansville & Crawfordsville Railroad, was opened to Terre Haute.There was a continuous human presence in the area that became Evansville from at least 8,000 BC by Paleo-Indians. The land encompassing Evansville was formally relinquished by the Delaware in 1805 to General William Henry Harrison, then governor of the Indiana Territory.